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eISSN: 2719-3209
ISSN: 0023-2157
Klinika Oczna / Acta Ophthalmologica Polonica
Bieżący numer Archiwum Filmy Artykuły w druku O czasopiśmie Suplementy Rada naukowa Recenzenci Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac Opłaty publikacyjne Standardy etyczne i procedury
Panel Redakcyjny
Zgłaszanie i recenzowanie prac online
SCImago Journal & Country Rank
2/2005
vol. 107
 
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Artykuł oryginalny

Podspojówkowe zastosowanie 5-fluorouracylu po leczeniu operacyjnym jaskry metodą sklerektomii głębokiej – wskazania, powikłania, wstępna ocena skuteczności

Małgorzata Wojtulewicz
1
,
Marek Rękas
1
,
Joanna Wierzbowska
1

  1. Klinika Okulistyki Wojskowego Instytutu Medycznego w Warszawie
Klinika Oczna 2005, 107(4-6): 232-235
Data publikacji online: 2005/07/02
Pełna treść artykułu Pobierz cytowanie
 


Introduction
5-FU is an antimetabolite which increases efficacy of deep sclerectomy by inhibiting subconjuctival fibrosis and fibroblast proliferation. The objective of the study was to analyze glaucoma patients who had undergone sclerectomy and in a post-surgery period required subconjuctival 5-FU injections.

Material and methods
Out of 120 patients who had undergone deep sclerectomy between January through November 2004, 17 were included in the study since they required subconjuctival 5-FU injections in a postoperative period. The analysis comprised of: (1) indications for antimetabolite administration; (2) time that elapsed from the surgery to the first antimetabolite administration; (3) mean dosage; (4) complications observed; and (5) initial evaluation of the treatment.

Results
In 13 patients (76.4%), the indication for 5-FU application was persistent intraocular pressure exceeding 15 mmHg; in one patient (5.8%), the 5-FU treatment was started due to an abrupt increase of the pressure from hypotony; in 6 subjects (35.2%), it was the thickening and vascular dilatation in the filtering bleb; in one subject (5.8%) encapsulated filtering bleb. Mean time of administering 5-FU was between the 2nd and 3rd week following surgery. Mean number of injectctions applied was 3.7 (18.5 mg 5-FU). The following complications were encountered: corneal superficial punctuate keratopathy (6 subjects), choroidal detachment (1 person), irregular astigmatism (1 person). In most cases IOP was well controlled by the end of the follow-up period (≤ 15 mmHg).

Conclusions
5-FU is safe and does not increase the perioperative risk, and has turned out to be effective in most cases of increased scarring in the filtering bleb site.

słowa kluczowe:

jaskra, sklerektomia głęboka, 5-fluorouracyl, dysfunkcja pęcherzyka filtracyjnego

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