eISSN: 2391-6052
ISSN: 2353-3854
Alergologia Polska - Polish Journal of Allergology
Current issue Archive Manuscripts accepted About the journal Supplements Special issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
3/2024
vol. 11
 
Share:
Share:
abstract:
Review paper

The role of exogenous histamine in atopic dermatitis flare-ups

Zofia Kowalska
1
,
Joanna Narbutt
2

  1. Polish Society of Atopic Diseases
  2. Department of Dermatology, Paediatric Dermatology and Oncological Dermatology, Medical University of Lodz, Lodz, Poland
Alergologia Polska – Polish Journal of Allergology 2024; 11, 3: 251–256
Online publish date: 2024/08/28
View full text Get citation
 
PlumX metrics:
Atopic dermatitis (AD) remains a significant challenge due to its chronic and relapsing nature, with various triggers exacerbating symptoms. While endogenous histamine’s role in AD is well documented, the impact of exogenous histamine remains controversial. This review explores the complex relationship between exogenous histamine and AD flare-ups, evaluating evidence for implementing low-histamine diets and diamine oxidase enzyme supplementation as a potential therapeutic intervention in a subgroup of AD patients. Histamine’s diverse physiological functions, its involvement in AD pathophysiology, and the potential implications of histamine intolerance and histamine overlay syndrome are examined. Studies suggest compromised metabolism and increased sensitivity to dietary histamine, highlighting the potential of low-histamine diets in managing symptoms. Despite limited research, preliminary findings underscore the need for further exploration of histamine-related reactions in AD and the therapeutic potential of low-histamine diets. Future research avenues include developing reliable screening tools and elucidating the relationships between gut microbiome dysbiosis and histamine metabolism in AD.
keywords:

atopic dermatitis, histamine intolerance, low-histamine diet, diamine oxidase



Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.