eISSN: 2391-6052
ISSN: 2353-3854
Alergologia Polska - Polish Journal of Allergology
Bieżący numer Archiwum Artykuły zaakceptowane O czasopiśmie Suplementy Zeszyty specjalne Rada naukowa Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac Opłaty publikacyjne Standardy etyczne i procedury
Panel Redakcyjny
Zgłaszanie i recenzowanie prac online
3/2023
vol. 10
 
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Artykuł oryginalny

Wpływ czułości alergenu Aspergillus fumigatus na alergiczny nieżyt nosa i astmę: retrospektywe jednoośrodkowe badanie

Osman Ozan Yeğit
1
,
Özlem Özdedeoğlu
1

  1. Department of Allergy and Clinical Immunology, Başakşehir Çam ve Sakura City Hospital, Istanbul, Turkey
Alergologia Polska – Polish Journal of Allergology 2023; 10, 3: 167–172
Data publikacji online: 2023/09/30
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Introduction:
Aspergillus fumigatus (A.f) is a common aeroallergen that can cause diseases such as allergic asthma, allergic rhinitis, and allergic bronchopulmonary aspergillosis (ABPA).

Aim:
To investigate the clinical characteristics of patients with A.f sensitivity and allergic respiratory diseases in the Istanbul region of Turkey.

Material and methods:
Patients with allergic rhinitis and A.f sensitivity, and patients with allergic rhinitis and sensitivities other than A.f were included in the study. Comparisons were conducted between A.f sensitive and A.f non-sensitive patients in terms of severity of allergic asthma, severity of allergic rhinitis, rhinitis visual analogue symptom (VAS) symptom scores, asthma and allergic rhinitis treatment steps, asthma frequency and asthma control.

Results:
A total of 157 patients with allergic rhinitis were included in the study. The median (IQR) age of the patients was 33 (25–45), and 106 of them were female (67.5%). Severe asthma was more frequent in patients with A.f sensitivity than in patients with other allergen sensitivities (p < 0.001). Presence of A.f sensitivity was related to a lower asthma control score and higher asthma treatment step than presence of other allergen sensitivities (p = 0.029, p < 0.001, respectively). Additionally, VAS symptom scores for allergic rhinitis before and after treatment and allergic rhinitis medication scores were higher in patients with A.f sensitivity than in patients without A.f sensitivity (p < 0.001, p = 0.015, p > 0.001, respectively).

Conclusions:
A.f sensitivity is associated with severe respiratory allergies. Clinicians should closely monitor these patients and remain vigilant for treatment unresponsiveness, exacerbations, and the potential progression of the disease to more complex clinical conditions such as ABPA.



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